Adipose Tissue Denervation Blunted the Decrease in Bone Formation Promoted by Obesity in Rats

The impact of obesity upon bone metabolism is controversial since both beneficial or harmful effects have been reported. Bone remodeling modulated by the central nervous system through cytokines, hormones and neuromodulators. present study aimed to evaluate evoked bilateral retroperitoneal white adipose tissue (rWAT) denervation (Dnx) mineral in an experimental model rats. Male Wistar rats were fed during 18 weeks with high-fat diet (HFD) standard (SD) as controls, rWAT Dnx Sham surgery was performed at 14th week. Biochemical hormonal parameters, histomorphometry, hypothalamus protein gene expression analyzed. HFD group presented decreased formation increased serum leptin FGF23, hypothalamic neuropeptide Y (NPY) 1,25-dihydroxyvitamin D3 PTH. After Dnx, markers histomorphometry showed restoration formation, NPY decreased, without alteration levels. shows that improved obese mediated a preferential reduction neurohormonal actions NPY, emphasizing relevance tissue–brain–bone axis control obesity.